Allopurinol

Indications :

• Hyperuricemia/Gout
• TLS prophylaxis

Contraindications:

Dosing :

• For gout: Treat to target urate goal of <6 (or <5 if +tophi)

MoA :

Pharmacokinetics :

Toxicities/Monitoring :

• Can cause SJS/TENS, particularly in pts with HLA-B58:01 (more common in Southeast Asian and African American descent).
  • The 2020 update to the American College of Rheumatology Guideline for the Management of Gout conditionally recommends HLA-B58:01 allele testing before initiating allopurinol for patients of reported Southeast Asian and African American (other sources say Han Chinese, Korean, Thai) descent and recommends against testing other patient populations

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