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Presentation :
- Rapidly progressive glomerulonephritis
- Has also been associated with pulmonary disease (Goodpasture syndrome ), often presenting with cough, SoB , or hemoptysis
Pathophysiology :
Diagnostic Testing:
- Anti-GBM antibody titers. Can trend to assess response to treatment.
- Test for ANCAs, double positivity carries worse prognosis
- Classically, Kidney biopsy shows necrotizing and crescentic glomerulonephritis with linear staining for IgG on immunofluorescence.
Treatment :
- Successful treatment, which typically includes glucocorticoids, plasmapheresis, and cyclophosphamide, will eradicate the patient's serum anti-GBM antibody titer.
Prognosis:
References: