CyBorD

Cy - Cyclophosphamide (Cytoxan)
Bor - Bortezomib (Velcade)
D - Dexamethasone

Indications :

• Treatment of [Multiple Myeloma] to alleviate symptoms and slow the progression, not curative intent.

Contraindications:

Dosing :

• Cyclophosphamide (tablets or capsules) by mouth once daily on Days 1, 8, 15, and 22
• Bortezomib (Velcade) subcutaneous injection on Days 1, 4, 8, and 11
• Dexamethasone 40 mg (ten 4 mg tablets) by mouth on Days 1, 2, 3, 4, then 9, 10, 11, 12, then 17, 18, 19 and 20

MoA :

Pharmacokinetics :

Toxicities/Monitoring :

• After treatment, patients who respond to CyBorD are typically monitored in the clinic using blood tests, continue on to maintenance therapy, or proceed to bone marrow transplant.
• Bortezomib (Velcade) can cause reactivation of herpes simplex virus (HSV) or varicella zoster virus (VZV). Prophylactic  anti-virals such as (acyclovir) should be taken during treatment
• For Dexamethasone, prophylaxis includes Bactrim for PJP and PPI for GI bleed

References:

• https://www.chemoexperts.com/cybord.html