Diabetic Amyotrophy

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Presentation :

• Acute onset of severe asymmetric pain or proximal weakness in a leg with associated muscle wasting.
• Many patients with LRPN report clinical symptoms that reflect autonomic and sensory nerve involvement:
  • Orthostatic hypotension
  • Tachycardia
  • Urinary and/or sexual dysfunction
  • Constipation or diarrhea
• Unintentional weight loss is common. Weight loss of >10 pounds has been reported to occur in up to 85 percent of patients in some series

Pathophysiology :

• Results from damage to lumbosacral plexus 2/2 infarction or immune vasculopathy

Diagnostic Testing:

Treatment :

• Supportive care

Prognosis:

References:

• Symptoms may progress for six months or longer before improving gradually, with at least partial recovery occurring in most patients