Flag-IDA

FL - Fludarabine
A - Cytarabine (Ara-C)
G - Granulocyte colony stimulating factor (G-CSF, filgrastim)
IDA - Idarubicin

Indications :

Contraindications:

Dosing :

• Fludarabine intravenous (I.V.) infusion over 30 minutes on Days 1, 2, 3, 4 and 5
• Cytarabine I.V. infusion over four hours (starting four hours after fludarabine) on Days 1, 2, 3, 4 and 5
• Idarubicin IVP over 10-15 minutes on Days 1, 2 and 3
• G-CSF (Filgrastim) subcutaneous injection once daily starting 24 hours either the day before or the day of chemotherapy, and continuing daily until Day 5. In some instances, G-CSF may be restarted seven days after chemotherapy and continued until the neutrophil count returns to normal range
• Since fludarabine and cytarabine must be separated by four hours, it can take up to 9 hours to finish treatment each day

MoA :

Pharmacokinetics :

Toxicities/Monitoring :

References:

• https://www.chemoexperts.com/flag-ida-fludarabine-arac-gcsf-idarubicin.html