HiDAC

High Dose Ara-C

See: Cytarabine (Ara-C)

Indications :

• Consolidation chemo for leukemia

Contraindications:

Dosing :

• Cytarabine intravenous infusion, usually given over three hours every 12 hours on Days 1, 3, and 5 (six doses total)
  • For patients with advanced age (e.g. > 60 years old) or with a history of multiple medical problems, the dose of cytarabine may be decreased
  • HiDAC usually requires a 5-day stay in a hospital.
• Each cycle is 28 to 35 days and treatment may required 3-4 cycles, depending upon the response or if the plan is for BMT.

MoA :

Pharmacokinetics :

Toxicities/Monitoring :

• Pancytopenia, neutropenic fever
• Cytarabine does NOT usually cause hair loss. Hair often begins to grow back during HiDAC chemotherapy

References:

• https://www.chemoexperts.com/hidac-high-dose-ara-c.html