Polycystic Ovary Syndrome (PCOS)

Search DocQuery

Presentation :

• Hyperandrogenism (hirsutism, acne)
• Amenorrhea, oligomenorrhea, infertility
• Associated with metabolic syndrome (DM2, HLD, obesity, OSA)

Pathophysiology :

Diagnostic Testing:

• Patients should be screened for diabetes, dyslipidemia, obesity, hypertension, and OSA.
• in women with rapidly progressive hirsutism or virilization measure serum testosterone and DHEAS
  • An androgen-secreting ovarian or adrenal tumor should be suspected in a woman with acute onset of rapidly progressive hirsutism or virilization.

Treatment :

• Weight loss is a first-line intervention.
• Metformin for prediabetes/diabetes
• If fertility is not desired, choose oral contraceptive for treatment of hirsutism and regulation of menses
  • Add spironolactone if hirsutism remains a problem
• If fertility is desired, ovulation can be induced with clomiphene citrate or letrozole

Prognosis:

References: