Travel Vaccinations

• Recommended According to Destination, Itinerary, and Purpose of Travel

  • Hepatitis A: first dose as soon as travel is considered, booster at 6-12 months (Havrix) or 6-18 months (Vaqta); or 0, 1 month, and 6 months for HepA-HepB combination (Twinrix)
  • Hepatitis B: 0, 1 month (Heplisav-B); or 0, 1 month, 6 months (Engerix-B, Recombivax-HB); or 0, 1 month, and 6 months for HepA-HepB combination (Twinrix)
  • Typhoid: Live-attenuated oral vaccine (Ty21a); 0, 2 days, 4 days, 6 days; capsular Vi polysaccharide intramuscular vaccine; one dose (preferred for immunocompromised persons)
  • Cholera: Live oral, 10 days before travel; killed oral, whole-cell-B subunit; 0, 1 week (available outside the United States)
  • Rabies: Inactivated; 0, 7 days, 21-28 days
  • Japanese encephalitis: Inactivated; 0, 28 days (booster recommended ≥11 months with ongoing risk)
  • Polio: inactivated; single dose (IM or SQ) if primary series completed; two doses 4-8 weeks apart followed by third dose 6-12 months after second if previously unvaccinated
  • Measles: live-attenuated, two doses separated by 28 days (born after 1956 and no documentation of vaccination or evidence of immunity)
  • Dengue: three doses given 6 months apart; only in seropositive persons aged 9-45 years (not available in the United States)
  • Tick-borne encephalitis: Inactivated; three doses over 6-15 months, second dose ≥2 weeks after first if rapid immune response required (not available in the United States)

• Required for Certain Destinations

  • Yellow fever: Live attenuated; one dose (no booster required)
  • Meningococcal: Quadrivalent conjugate (MenACWY); one dose and revaccinate every 5 years if the risk persists

References:

• MKSAP