Type 1 Diabetes (DM1)

#med #disease #y2023

Presentation :

At diagnosis, one or more autoantibodies directed at the following targets are typically present: glutamic acid decarboxylase (GAD65), tyrosine phosphatases IA-2 and IA-2β, islet cells, insulin, and zinc transporter
Because of highly automated and widely available assays, GAD65 and IA-2 autoantibodies are recommended as initial testing. GAD65 autoantibodies have a high prevalence (70%) at the time of diagnosis and may remain detectable for years.
Eventually β-cell function declines to the point of little to no insulin secretion, as evidenced by a low or undetectable serum C-peptide level.

Increased risk for other autoimmune disorders, including celiac disease, thyroid disorders, vitiligo, and autoimmune primary adrenal gland failure